Assist. Prof. Dr. Takahiro Horibe

Nagoya University

Graduate School of Engineering, Department of Molecular & Macromolecular Chemistry

Laboratory of Catalysis in Organic Synthesis

Assistant Professor


Professional Societies:

The Chemical Society of Japan (CSJ)

The Society of Synthetic Organic Chemistry, Japan (SSOCJ)

TEL +81-52-789-3334 / FAX +81-52-789-3222

Horibe Group Member (2019)

Shuhei Omura (D2), Yasutaka Tsuji (D2), Takashi Hazeyama (M2), Rin Hiramatsu (M2), Tatsuya Ishikawa (M1), Kei Katagiri (M1),  Haruna Kato (B4),  Kazuki Takeda (B4) 

Education/Academic Experience

1985 Born in Toyota city, Aichi

2004 Toyota Nishi Senior High School, Graduated

2008 School of Engineering, Nagoya University, Graduated

2010 Mr. of Eng., Department of Biotechnology, Nagoya University (Advisor: Prof. Kazuaki Ishihara)

2010 Visiting Student, Harvard University (Advisor: Prof. Tobias Ritter)
2013 Dr. of Eng., Department of Biotechnology, Nagoya University (Advisor: Prof. Kazuaki Ishihara)
Thesis: “Development of Chiral Lithium(I) and Magnesium(II) BINOLates for Catalytic Enantioselective Mannich-type Reaction and Hydrophosphonylation”

2013-2015 Post-Doctoral Fellow, University of California, Berkeley (Advisor: Prof. F. Dean Toste)
2015- Assistant Professor, Department of Biotechnology, Nagoya University


2013 CSJ Student Presentation Award 2013

2014 Reaxys PhD Prize, Finalist

2016 Fujifilm Corporation Award in Synthetic Organic Chemistry, Japan


10. Structure and Reactivity of Aromatic Radical Cations Generated by FeCl3
Takahiro Horibe, Shuhei Ohmura, Kazuaki Ishihara
J. Am. Chem. Soc. 2019, 141, 1877–1881.

DOI: 10.1021/jacs.8b12827

  • Ranked in the Top 20 most read articles in J. Am. Chem. Soc. based on the previous 30 days-records (Feb, 2019).
  • Press Release from Nagoya University
  • Highlighted in ChemStation.
  • Highlighted in Japanese Newspapers (Kagaku Kogyo Nippo, Nikkan Kogyo, Yahoo News).

9. Thiourea–I2 as Lewis base–Lewis acid cooperative catalysts for iodochlorination of alkene with in situ-generated I–Cl
Takahiro Horibe, Yasutaka Tsuji, Kazuaki Ishihara*
ACS Catalysis 2018, 8, 6362-6366.

DOI: 10.1021/acscatal.8b01565

  • Ranked in the Top 10 most read articles in ACS Catalysis based on the previous 30 days-records (10th July, 2018).
  • Highlighted in Synfacts 2018, 14(9), 976.

8. Selenium–Iodine Cooperative Catalyst for Chlorocyclization of Tryptamine Derivatives
Takahiro Horibe, Shuhei Ohmura, Kazuaki Ishihara*
Org. Lett. 2017, 19, 5525-5528.

DOI: 10.1021/acs.orglett.7b02613

7. Enantioselective Cyanosilylation of Ketones with Lithium(I) Dicyanotrimethylsilicate(IV) Catalyzed by a Chiral Lithium(I) Phosphoryl Phenoxide
Manabu Hatano, Katsuya Yamakawa, Tomoaki Kawai, Takahiro Horibe, Kazuaki Ishihara*
Angew. Chem. Int. Ed. 2016, 55, 4021-4025.

DOI: 10.1002/anie.201510682

6. Gold(I)-Catalyzed Enantioselective [3+2] and [3+3] Cycloaddition Reactions of Propargyl Acetals/Ketals
Cristina Navarro, Nathan D. Shapiro, Maurizio Bernasconi, Takahiro Horibe, F. Dean Toste
Tetrahedron 2015, 71, 5800-5805.

  • Special Issue: 2014 Tetrahedron Prize for Creativity in Organic Chemistry, Palladium and Other Transition Metal-Catalyzed Reactions: Methods and Applications

5. Stable gold(III) catalysts by oxidative addition of a carbon–carbon bond

Chung-Yeh Wu*, Takahiro Horibe* , Christian B. Jacobsen, F. Dean Toste

*These authors contributed equally

Nature. 2015, 517, 449-454. 

DOI: 10.1038/nature14104

  • News and Views "Catalysis: Gold unleashes the power of three" by Christopher M. B. K. Kourra & Nicolai Cramer in Nature.
  • Highlighted "Oxidative Addition to Gold(I): A New Avenue in Homogeneous Catalysis with Au" by J. Henrique Teles in Angew. Chem. Int. Ed.

4. Chiral Supramolecular Magnesium(II) Binaphtholate Catalysts for the Enantioselective Direct Mannich-Type Reaction and Hetero-Diels–Alder Reaction
Manabu Hatano, Takahiro Horibe, Kenji Yamashita, Kazuaki Ishihara
Asian J. Org. Chem. 2013, 2, 952-956.

  • Special Issue: 40 Years of the Mukaiyama Aldol Reaction, 1973–2013

3. Chiral Magnesium(II) Binaphtholates as Cooperative Brønsted/Lewis Acid–Base Catalysts for the Highly Enantioselective Addition of Phosphorus Nucleophiles to α,β-Unsaturated Esters and Ketones
Manabu Hatano, Takahiro Horibe, Kazuaki Ishihara
Angew. Chem. Int. Ed.. 2013, 52, 4549-4553.

2. Magnesium(II)-Binaphtholate as a Practical Chiral Catalyst for the Enantioselective Direct Mannich-Type Reaction with Malonates
Manabu Hatano, Takahiro Horibe, Kazuaki Ishihara
Org. Lett. 2010, 12, 3502-3505.

1. Chiral Lithium(I) Binaphtholate Salts for the Enantioselective Direct Mannich Type Reaction with a Change of Syn/Anti and Absolute Stereochemistry
Manabu Hatano, Takahiro Horibe, Kazuaki Ishihara
J. Am. Chem. Soc. 2010, 132, 56-57.


External Grants







Postdoctoral and graduate students is being recruited.In our laboratory will be accepted at any time undergraduate, graduate student visits to laboratories.Those who wish, please contact us by e-mail to Professor Ishihara.



国立大学法人 東海国立大学機構


大学院工学研究科 有機・高分子化学専攻(工学部 化学生命工学科)


〒464-8603 名古屋市千種区不老町



Laboratory of Catalysis in Organic Synthesis, Research Group of Molecular Chemistry, Graduate Department of Molecular and Macromolecular Chemistry, Graduate School of Engineering (Undergraduate Department of Chemistry and Biotechnology, School of Engineering), Nagoya University

Tokai National Higher Education and Research System

B2-3(611), Furo-cho, Chikusa, Nagoya 464-8603, Japan