Ishihara World: Rational Design of High-Performance Catalysts

Based on Acid–Base Combination Chemistry

Top News

"Enantio- and Diastereoselective Carbonyl-Ene Cyclization–Acetalization Tandem Reaction Catalyzed by Tris(pentafluorophenyl)borane-Assisted Chiral Phosphoric Acids"

Hideyuki Ishihara, Jianhao Huang, Takuya Mochizuki, Manabu Hatano*, and Kazuaki Ishihara*
ACS Catal. 2021, 11(10), 6121–6127 (Publication Date:May 6, 2021).

Kazuki Nishimura received the CSJ Student Presentation Award 2021 on March 31, 2021.

A20-2am-08 "Enantioselective α-Halogenation of N-Acyl-3,5-dimethylpyrazoles Catalyzed by Chiral π-Cu(II)-π Complexes"


有機合成化学協会誌 2021, 79(4), 356.

"The C-N Ring Construction: The Soós Synthesis of Aspidofractinine"

Organic Chemistry Portal [Organic Chemistry Highlights] Douglass F. Taber, University of Delaware, Monday, April 12, 2021
"Kazuaki Ishihara of Nagoya University prepared the pyrrolidine 9 by combining the enone 7 with the propargyl sulfonamide 8 (Angew. Chem. Int. Ed. 2020, 59, 16470. DOI: 10.1002/anie.202007180)."

大村修平、令和2年度 博士課程教育リーディングプログラム グリーン自然科学国際教育研究プログラム(IGER)を修了








Farewell Party with Prof. K. Ishihara on March 23, 2021.


今 利真 博士 来研


"Insight into the Mechanism of the Acylation of Alcohols with Acid Anhydrides Catalyzed by Phosphoric Acid Derivatives"

Hiroyuki Hayashi, Shotaro Yasukochi, Tatsuhiro Sakamoto, Manabu Hatano*, and Kazuaki Ishihara*
J. Org. Chem. 2021, 86(7), 5197–5212.
DOI: 10.1021/acs.joc.1c00102 (Publication Date: March 15, 2021)



“Insight into the mechanism of the acylation of alcohols with acid anhydrides catalyzed by phosphoric acid derivatives”
Hiroyuki Hayashi, Shotaro Yasukochi, Tatsuhiro Sakamoto, Manabu Hatano,* Kazuaki Ishihara*
J. Org. Chem. 2021, Manuscript Accepted.

大村修平(D3)が第11回 大津会議 Otsu Conference 2020 ─有機合成の夢を語る─に参加しました。なお、開催時期が2021年2月22-23日に変更となり、オンラインで実施されました。

▼"Chiral organoiodine-catalyzed enantioselective oxidative dearomatization of phenols"

Muhammet Uyanik, Shinichi Ishizaki, and Kazuaki Ishihara*

Org. Synth. 2021, 98, 28–50.

DOI: 10.15227/orgsyn.098.0028 (Published on the Web 2/27/2021)

▼"Synthesis of chiral organoiodine catalyst for enantioselective oxidative dearomatization reactions: N,N'-(2S,2S')-(2-iodo-1,3-phenylene)bis(oxy)bis(propane-2,1-diyl)bis(2,4,6-trimethylbenzamide)"

Muhammet Uyanik, Shinichi Ishizaki and Kazuaki Ishihara*
Org. Synth. 2021, 98, 1–27
DOI: 10.15226/orgsyn.098.0001 (Published on the Web 2/25/2021)

▼[Researcher Profile] Kazuaki Ishihara
Asia Research News
First published: 6 February 2021

The "Mix-Lab" joint research project between Kamigaito group and our group has started since January, 2021.

GTRの支援によって実験室(912, 913)と居室(905)が整備されました



Welcome to our laboratory, Weiwei GUO (D1 of G30 program, China Scholarship Council (中国政府派遣留学生).

He graduated master course in Shaanxi Normal University, P. R. China.

▼【未来の研究者The Researchers of The Future】


press e 2020, No. 46, 16–16

Chemoselective Transesterification of Methyl (Meth)acrylates Catalyzed by Sodium(I) or Magnesium(II) Aryloxides

Jie Qi Ng, Hiro Arima, Takuya Mochizuki, Kohei Toh, Kai Matsui, Manussada Ratanasak, Jun-Ya Hasegawa*, Manabu Hatano*, and Kazuaki Ishihara*
ACS Catal. 2021, 11(1), 199–207
DOI: 10.1021/acscatal.0c04217 (Publication Date: December 16, 2020)


触媒的エステル交換法を用いる(メタ)アクリル酸エステルの効率合成~ 低環境負荷製造技術を推進 ~


触媒的エステル交換法を用いる(メタ)アクリル酸エステルの効率合成~ 低環境負荷製造技術を推進 ~


見出し「(メタ)アクリル酸エステル 高効率合成法を開発 名古屋大など 常温・無溶剤で」

Asia Research News(2021年2月10日(水))

Headline "Industrial compound gets eco-friendly reaction" 
Scientists have found catalysts that improve an important industrial reaction and make it more eco-friendly.






Postdoctoral and graduate students is being recruited.In our laboratory will be accepted at any time undergraduate, graduate student visits to laboratories.Those who wish, please contact us by e-mail to Professor Ishihara.



国立大学法人 東海国立大学機構


大学院工学研究科 有機・高分子化学専攻(工学部 化学生命工学科)


〒464-8603 名古屋市千種区不老町



Laboratory of Catalysis in Organic Synthesis, Research Group of Molecular Chemistry, Graduate Department of Molecular and Macromolecular Chemistry, Graduate School of Engineering (Undergraduate Department of Chemistry and Biotechnology, School of Engineering), Nagoya University

Tokai National Higher Education and Research System

B2-3(611), Furo-cho, Chikusa, Nagoya 464-8603, Japan